| Title: | Association of Hematopoietic Loss of Y Chromosome With Atrial Fibrillation Incidence and Sex Disparity |
| Journal: | JACC Basic to Translational Science |
| Published: | 15 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40139870/ |
| DOI: | https://doi.org/10.1016/j.jacbts.2024.10.012 |
Publication 14894
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Abstract
Mosaic loss of chromosome Y (mLOY), the most common somatic mutation, prompts fibrotic heart diseases. We hypothesized that it accelerates atrial fibrillation (AF) and contributes to its sex disparity. A total of 214,405 male participants from the UK Biobank without prevalent AF were included, with a median follow-up of 14.31 years. mLOY was associated with a 16% higher AF risk, with 9.6% and 6.4% of the association mediated by neutrophils and monocytes. AF risk of males with mLOY was 98% higher than that of matched females. Thus, mLOY is associated with a slightly increased AF risk, and might partly contribute to sex disparity of AF.</p>
7 Authors
- Tianqi Ma
- Chen Zhu
- Xunjie Cheng
- Yuanfeng Huang
- Jinchen Li
- Yu Tan
- Yongping Bai
1 Application
| Application ID | Title |
|---|---|
| 84443 | Lifestyles, Environmental Exposures, and Psychological Factors, and Genetic-Environmental Relationships in Aging-Related Diseases |
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