| Title: | Genome-wide association analysis of composite sleep health scores in 413,904 individuals |
| Journal: | Communications Biology |
| Published: | 24 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39856408/ |
| DOI: | https://doi.org/10.1038/s42003-025-07514-0 |
Publication 14934
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Recent genome-wide association studies (GWASs) of several individual sleep traits have identified hundreds of genetic loci, suggesting diverse mechanisms. Moreover, sleep traits are moderately correlated, so together may provide a more complete picture of sleep health, while illuminating distinct domains. Here we construct novel sleep health scores (SHSs) incorporating five core self-report measures: sleep duration, insomnia symptoms, chronotype, snoring, and daytime sleepiness, using additive (SHS-ADD) and five principal components-based (SHS-PCs) approaches. GWASs of these six SHSs identify 28 significant novel loci adjusting for multiple testing on six traits (p < 8.3e-9), along with 341 previously reported loci (p < 5e-08). The heritability of the first three SHS-PCs equals or exceeds that of SHS-ADD (SNP-h2 = 0.094), while revealing sleep-domain-specific genetic discoveries. Significant loci enrich in multiple brain tissues and in metabolic and neuronal pathways. Post-GWAS analyses uncover novel genetic mechanisms underlying sleep health and reveal connections (including potential causal links) to behavioral, psychological, and cardiometabolic traits.</p>
8 Keywords
- Adult
- Female
- Genome-Wide Association Study
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Sleep
26 Authors
- Matthew O. Goodman
- Tariq Faquih
- Valentina Paz
- Pavithra Nagarajan
- Jacqueline M. Lane
- Brian Spitzer
- Matthew Maher
- Joon Chung
- Brian E. Cade
- Shaun M. Purcell
- Xiaofeng Zhu
- Raymond Noordam
- Andrew J. K. Phillips
- Simon D. Kyle
- Kai Spiegelhalder
- Michael N. Weedon
- Deborah A. Lawlor
- Jerome I. Rotter
- Kent D. Taylor
- Carmen R. Isasi
- Tamar Sofer
- Hassan S. Dashti
- Martin K. Rutter
- Susan Redline
- Richa Saxena
- Heming Wang
1 Application
| Application ID | Title |
|---|---|
| 6818 | Sleep and chronotype and their causal links with cardiometabolic and chronic inflammatory diseases |
Enabling scientific discoveries that improve human health