| Title: | The X chromosome's influences on the human brain |
| Journal: | Science Advances |
| Published: | 24 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39854466/ |
| DOI: | https://doi.org/10.1126/sciadv.adq5360 |
Publication 14937
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Abstract
Genes on the X chromosome are extensively expressed in the human brain. However, little is known for the X chromosome's impact on the brain anatomy, microstructure, and functional networks. We examined 1045 complex brain imaging traits from 38,529 participants in the UK Biobank. We unveiled potential autosome-X chromosome interactions while proposing an atlas outlining dosage compensation for brain imaging traits. Through extensive association studies, we identified 72 genome-wide significant trait-locus pairs (including 29 new associations) that share genetic architectures with brain-related disorders, notably schizophrenia. Furthermore, we found unique sex-specific associations and assessed variations in genetic effects between sexes. Our research offers critical insights into the X chromosome's role in the human brain, underscoring its contribution to the differences observed in brain structure and functionality between sexes.</p>
10 Keywords
- Brain
- Chromosomes, Human, X
- Female
- Genome-Wide Association Study
- Humans
- Magnetic Resonance Imaging
- Male
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
- Schizophrenia
15 Authors
- Zhiwen Jiang
- Patrick F. Sullivan
- Tengfei Li
- Bingxin Zhao
- Xifeng Wang
- Tianyou Luo
- Shuai Huang
- Peter Y. Guan
- Jie Chen
- Yue Yang
- Jason L. Stein
- Yun Li
- Dajiang Liu
- Lei Sun
- Hongtu Zhu
1 Application
| Application ID | Title |
|---|---|
| 22783 | The joint analysis of imaging data and genetic data for early tumor detection, prevention, diagnosis and treatment |
Enabling scientific discoveries that improve human health