| Title: | Circulating insulin-like growth factor-1 and the risk of multiple sclerosis: a prospective cohort study |
| Journal: | Multiple Sclerosis and Related Disorders |
| Published: | 27 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39884114/ |
| DOI: | https://doi.org/10.1016/j.msard.2025.106281 |
Publication 14944
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Abstract
BACKGROUND: Circulating insulin-like growth factor 1 (IGF-1) is positively associated with the risks of certain neurological disorders, including stroke, Alzheimer's disease, and Parkinson's disease. However, the association of IGF-1 with the risk of multiple sclerosis (MS) remains unclear.</p>
METHODS: A total of 348,324 participants at baseline were included from the UK biobank in this prospective study. The association of circulating IGF-1 level with MS was analyzed by Cox proportional hazard models. Further, subgroup analyses were conducted to investigate the variables influencing these associations.</p>
RESULTS: Among 348,324 individuals, lower circulating IGF-1 concentrations were associated with a reduced risk of MS (95 % CI, 0.5930-0.9700; P value = 0.02763). The association between lower IGF-1 levels and reduced risk of MS remains robust in older and female participants. Moreover, risk of MS appeared to be lower in IGF-1-low individuals who never smoked, currently drinking alcohol, with higher body mass index, and higher glucose concentrations.</p>
CONCLUSION: Our findings indicate that a lower concentration of serum IGF-1 was associated with a reduced risk of MS. The results provide evidence that the circulating IGF-1 may play a significant role in the pathogenesis of MS.</p>
12 Keywords
- Adult
- Aged
- Female
- Humans
- Insulin-Like Growth Factor I
- Insulin-Like Peptides
- Male
- Middle Aged
- Multiple Sclerosis
- Prospective Studies
- Risk Factors
- United Kingdom
12 Authors
- Xiao-Wei Pang
- Sheng Yang
- Lu-Yang Zhang
- Lian Chen
- Li-Fang Zhu
- Yun-Hui Chu
- Ming-Hao Dong
- Luo-Qi Zhou
- Jun Xiao
- Wei Wang
- Chuan Qin
- Dai-Shi Tian
1 Application
| Application ID | Title |
|---|---|
| 94533 | A Study of risk factors for cardiovascular and cerebrovascular diseases |
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