| Title: | The obesity paradox in osteoporosis risk among older adults is mostly driven by women: a population-based prospective study |
| Journal: | BMC Geriatrics |
| Published: | 27 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39871185/ |
| DOI: | https://doi.org/10.1186/s12877-025-05704-3 |
Publication 14946
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Abstract
ObjectivesThe obesity paradox is common among older adults at risk for various diseases. Although this paradox has also been observed in the association between obesity and osteoporosis, the available evidence remains controversial. This study aimed to investigate the association between obesity and OP risk in an older population.MethodsA cross-sectional and prospective study was conducted using data from 177,734 participants in the UK Biobank. The association of body mass index (BMI), waist circumference (WC), and fat percentage with BMD was examined using Spearman correlation analysis with baseline BMD data. Cox proportional hazards regression analysis was used to investigate the association between obesity and OP risk. Restricted cubic spline (RCS) were used to assess the nonlinear associations of BMI, WC, and fat percentage with OP.ResultsBaseline cross-sectional analyses revealed a significant positive association between BMI, WC, and fat percentage with BMD in women, whereas this association was very weak in men. A total of 8,998 OP patients were identified during a median follow-up period of 13.7 years. Cox analyses showed that obesity as defined by BMI, WC, and fat percentage was associated with a 33%, 23%, and 31% reduction in the risk of OP in older women but not in men, respectively. Conjoint analysis showed that lower BMI was associated with increased risk of OP in older adults, whereas the lowest risk was observed in women with higher BMI and higher body fat. RCS revealed an inverse J-shaped nonlinear association between obesity metrics and OP risk in women.ConclusionLower BMI is an independent risk factor for OP in older adults, and the obesity paradox for OP risk exists only in women.</p>
16 Keywords
- Aged
- Body Mass Index
- Bone Density
- Cross-Sectional Studies
- Female
- Humans
- Male
- Middle Aged
- Obesity
- Obesity Paradox
- Osteoporosis
- Prospective Studies
- Risk Factors
- Sex Factors
- United Kingdom
- Waist Circumference
11 Authors
- Qingfeng Luo
- Shiyong Zhang
- Zixin Liang
- Danni Wang
- Yanlin Zhong
- Bin Xia
- Peng Xie
- Can Wang
- Jinqiu Yuan
- Ziji Zhang
- Xingsheng Li
1 Application
| Application ID | Title |
|---|---|
| 51671 | Metabolism syndrome and risk of cancer |
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