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Abstract
Persons with Obstructive Lung Disease (OLD) had signi?cantly worse cognitive function scores than persons without OLD on prospective memory [b e0.15 (e0.22 to e0.09)], visuospatial memory [b round 1 0.06 (0.03?0.10)]; b round 2 0.09 (<0.001?0.18)), numeric short-term memory [b ?0.05 (?0.10 to <0.001)] and cognitive processing speed [b 4.62 (1.25?8.01)] after correction for possible confounders. Impairment in prospective memory [b 0.004 (<0.001?0.01)] and numeric short-term memory [b 0.01 (0.003?0.01)] were weakly related to FEV1 (adjusted P < .05). Persons with OLD experience cognitive impairment in different domains, which is partially related to airway obstruction. In particular, memory and information processing are affected. Further assessment of the relationship with patient-related outcomes is needed to optimize patient-oriented treatment.