| Title: | Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank: A Mendelian Randomization Study |
| Journal: | JAMA Cardiol |
| Published: | 1 Aug 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28678979/ |
| DOI: | https://doi.org/10.1001/jamacardio.2016.5804 |
Publication 1682
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Abstract
Of the 119,859 individuals included in the study, 56,816 (47.4%) were men; mean (SD) age was 56.87 (7.93) years. Mendelian randomization analysis showed significant positive associations between genetically instrumented higher BMI and risk of hypertension, coronary heart disease and type 2 diabetes, as well as systolic blood pressure and diastolic blood pressure. These associations were independent of age, sex, Townsend deprivation scores, alcohol intake, and smoking history. The results of this study add to the burgeoning evidence of an association between higher BMI and increased risk of cardiometabolic diseases. This finding has relevance for public health policies in many countries with increasing obesity levels.1 Author
- Lyall DM et al.
1 Application
| Application ID | Title |
|---|---|
| 7155 | Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
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