| Title: | Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort |
| Journal: | Translational Psychiatry |
| Published: | 2 Feb 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29391395/ |
| DOI: | https://doi.org/10.1038/s41398-017-0079-1 |
| URL: | https://www.nature.com/articles/s41398-017-0079-1.pdf |
| Citations: | 66 (17 in last 2 years) as of 8 Aug 2024 |
Publication 1982
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Abstract
Risk-taking behaviour is a key component of several psychiatric disorders and could influence lifestyle choices such as smoking, alcohol use, and diet. As a phenotype, risk-taking behaviour therefore fits within a Research Domain Criteria (RDoC) approach, whereby identifying genetic determinants of this trait has the potential to improve our understanding across different psychiatric disorders. Here we report a genome-wide association study in 116,255 UK Biobank participants who responded yes/no to the question "Would you consider yourself a risk taker?" Risk takers (compared with controls) were more likely to be men, smokers, and have a history of psychiatric disorder. Genetic loci associated with risk-taking behaviour were identified on chromosomes 3 (rs13084531) and 6 (rs9379971). The effects of both lead SNPs were comparable between men and women. The chromosome 3 locus highlights CADM2, previously implicated in cognitive and executive functions, but the chromosome 6 locus is challenging to interpret due to the complexity of the HLA region. Risk-taking behaviour shared significant genetic risk with schizophrenia, bipolar disorder, attention-deficit hyperactivity disorder, and post-traumatic stress disorder, as well as with smoking and total obesity. Despite being based on only a single question, this study furthers our understanding of the biology of risk-taking behaviour, a trait that has a major impact on a range of common physical and mental health disorders.</p>
19 Authors
- Rona J. Strawbridge
- Joey Ward
- Breda Cullen
- Elizabeth M. Tunbridge
- Sarah Hartz
- Laura Bierut
- Amy Horton
- Mark E. S. Bailey
- Nicholas Graham
- Amy Ferguson
- Donald M. Lyall
- Daniel Mackay
- Laura M. Pidgeon
- Jonathan Cavanagh
- Jill P. Pell
- Michael O'Donovan
- Valentina Escott-Price
- Paul J. Harrison
- Daniel J. Smith
1 Application
| Application ID | Title |
|---|---|
| 6553 | Genome-wide association studies of mental health. |
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