| Title: | Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization |
| Journal: | Allergy |
| Published: | 1 Jan 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28675761/ |
| DOI: | https://doi.org/10.1111/all.13242 |
Publication 2103
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Abstract
We included 490,497 participants in the observational and 162,124 participants in the genetic analyses. A genetic risk score (GRS) was created using 26 BMI-associated single nucleotide polymorphisms (SNPs). Results were pooled in meta-analyses and expressed as odds ratios (ORs) with 95% confidence interval (CI). The results support the conclusion that increasing body mass index is causally related to higher prevalence of asthma and decreased lung function, but not with hay fever or biomarkers of allergy.1 Author
- Skaaby T et al.
1 Application
| Application ID | Title |
|---|---|
| 17765 | Identifying causes of the allergy and asthma epidemics by using genetic biomarkers of exposures |
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