| Title: | Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: A Mendelian randomization investigation |
| Author: | Schooling CM et al. |
| Journal: | Int J Cardiol |
| Published: | 15 Sep 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29804699/ |
| DOI: | https://doi.org/10.1016/j.ijcard.2018.05.051 |
Publication 2157
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Summary
Testosterone supplementation has been linked to increased cardiovascular disease risk in some observational studies. We assessed genetic associations of variants in two gene regions that are predictors of testosterone (SHBG and JMJD1C) with several cardiovascular risk factors, coronary artery disease risk and ischaemic stroke risk. There was some evidence of an association for variants in these regions with risk of CAD and with ischaemic stroke in men. This implies that sex hormone-related mechanisms appear to be relevant to cardiovascular risk factors and for stroke (particularly for men). However, the extent that these findings are specifically informative about endogenous testosterone or testosterone supplementation is unclear.1 Application
| Application ID | |
|---|---|
| 14864 | Evaluation of the causal relation between hematocrit, hemoglobin, HbA1c, testosterone and cardiovascular outcomes in the UK Biobank using Mendelian randomization analysis |
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