| Title: | The dose-response association between wearables-quantified incidental physical activity and type 2 diabetes: a prospective cohort study |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 24 Sep 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42784530/ |
| DOI: | https://doi.org/10.1210/clinem/dgag316 |
| URL: | https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgag316/71382792/dgag316.pdf |
Publication 21775
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Abstract
AIM: This prospective cohort study aimed to quantify dose-response associations between intensity-specific incidental physical activity (IPA) and the incidence of type 2 diabetes (T2D) in a large cohort of UK adults. A secondary aim was to estimate the T2D-specific equivalence of 1 minute of vigorous-intensity IPA relative to moderate- and light-intensity IPA.</p>
METHODS: Participants were adults from the UK Biobank accelerometry sub-study who self-reported as nonexercisers. Individuals were excluded if they had T2D at baseline, were using insulin therapy, or received a T2D diagnosis within 12 months of follow-up. T2D status was primarily derived from primary care records. Device-measured IPA was categorized into light (LIPA; 1.5 to <3 METs), moderate (MIPA; 3 to <6 METs), and vigorous (VIPA; ≥6 METs) intensities. Additional analyses examined the T2D-specific equivalence of 1 minute of VIPA to MIPA and LIPA. The reference group comprised participants accumulating neither MIPA nor VIPA.</p>
RESULTS: The primary analysis included 22 857 nonexercisers (mean age 62.1 ± 7.7 years, 42.8% male). Over a 7.8-year follow-up period, 721 (3.2%) participants developed T2D. MIPA and VIPA, but not LIPA, exhibited near-linear inverse associations with T2D risk. Median VIPA (4.75 minutes/day) was associated with a hazard ratio (HR) 0.62 [95% confidence interval (CI) 0.53-0.73], and median MIPA (23.70 minutes/day) showed a HR of 0.67 (95% CI: 0.52-0.86). One minute of VIPA/day was associated with an equivalent T2D risk reduction of 5.9 minutes MIPA/day and 46.6 minutes LIPA/day.</p>
CONCLUSION: MIPA and VIPA were associated with lower T2D risk in a dose-dependent manner. Although median LIPA was linked to reduced risk, it did not demonstrate a consistent dose-response relationship.</p>
10 Authors
- Angelo Sabag
- Raaj Kishore Biswas
- Nicholas A Koemel
- Monique E Francois
- Shelley E Keating
- Martin J Gibala
- Jonathan P Little
- Nathan A Johnson
- Emmanuel Stamatakis
- Matthew N Ahmadi
1 Application
| Application ID | Title |
|---|---|
| 25813 | Integrated paradigms to investigate the interplay between lifestyle behaviours, the social environment, and genetic risk in the development of cardio- metabolic disease and mental health. |
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