| Title: | Genome-wide association study of habitual physical activity in over 377,000 UK Biobank participants identifies multiple variants including CADM2 and APOE |
| Journal: | Int J Obes (Lond) |
| Published: | 1 Jun 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29899525/ |
| DOI: | https://doi.org/10.1038/s41366-018-0120-3 |
Publication 2263
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Abstract
Physical inactivity is one of the most important risk factors for disease today. We undertook the largest genome-wide association study of habitual physical activity to date, in an effort to identify genes that may affect an individual s propensity to be physically active. Along with the genetic data from the UK Biobank, we used physical activity levels of each individual from the questionnaire responses and from the sensor that was worn for a week in a subset of UK Biobank participants. We identified over 20 genetic variants associated with these measures of habitual physical activity. Our results provide new insight into the genetic basis of habitual physical activity, and we hope will provide a foundation for a better understanding of the underlying biological mechanisms and of the links between physical activity and disease.1 Author
- Klimentidis YC et al.
1 Application
| Application ID | Title |
|---|---|
| 15678 | Genetic basis of circulating biomarkers, cardiometabolic disease, body composition and lifestyle |
Enabling scientific discoveries that improve human health