| Title: | Genetic Predisposition to High Blood Pressure and Lifestyle Factors: Associations With Midlife Blood Pressure Levels and Cardiovascular Events |
| Journal: | Circulation |
| Published: | 13 Feb 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29254930/ |
| DOI: | https://doi.org/10.1161/CIRCULATIONAHA.117.030898 |
Publication 2303
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Abstract
We constructed a genetic risk score for high BP by using 314 published BP loci in 277005 individuals without previous CVD from the UK Biobank study, a prospective cohort of individuals aged 40 to 69 years, with a median of 6.11 years of follow-up. We scored participants according to their lifestyle factors including body mass index, healthy diet, sedentary lifestyle, alcohol consumption, smoking, and urinary sodium excretion levels measured at recruitment. We examined the association between tertiles of genetic risk and tertiles of lifestyle score with BP levels and incident CVD by using linear regression and Cox regression models, respectively.1 Author
- Pazoki R et al.
1 Application
| Application ID | Title |
|---|---|
| 10035 | Risk factors and associated causal pathways linked to blood pressure |
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