| Title: | Predictors of mosaic chromosome Y loss and associations with mortality in the UK Biobank |
| Journal: | Sci Rep |
| Published: | 17 Aug 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30120341/ |
| DOI: | https://doi.org/10.1038/s41598-018-30759-1 |
Publication 2728
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Abstract
As men age, some of their blood cells lose the Y chromosome. Previous studies have identified potential health outcomes that may be more common in men with high levels of Y loss in their blood. We investigated potential risk factors that lead to increased Y loss as well as the potential impacts of mosaic Y loss on a variety of health conditions measured by the UK Biobank. Our findings suggest mosaic Y loss increases with age and smoking and could also be influenced by ancestry. Additionally, we find evidence that Y loss is a potential biomarker for several health-related outcomes including cancer risk and all-cause mortality.1 Author
- Loftfield E et al.
1 Application
| Application ID | Title |
|---|---|
| 21552 | Detection of large-scale copy-number and copy-neutral mosaic alterations in circulating leukocyte DNA of UK Biobank cancer cases and cancer-free controls |
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