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Abstract
Apolipoprotein e4 genotype is found in around 25% of the population, and is a known risk factor for increased risk of dementia. However, there is lack of large-scale, high quality data relating to how it affects brain structure and function in generally healthy, non-demented brains. Here, we looked at e4 genotype presence vs. absence, and found that it mostly associates with brain white matter hyperintensity volumes. It did not associate with gray matter, particularly. This means that at least in non-pathological ageing, APOE e4 seems to be affecting the brain through mostly a vascular-type health pathway (which is reflects to some extent by hyperintensity volume).