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A large international collaboration has tracked down 15 variations in the genome that are related to the risk of suffering osteoporotic fractures, a major healthcare problem affecting worldwide more than 9 million individuals every year. The collaboration went a step further and used genomic information on other risk factors to examine their causal role on developing fractures; finding that only bone mineral density and muscle strength are directly involved in fracture susceptibility. Genetic predisposition to other clinical risk factors like vitamin D levels and calcium intake, historically considered to be crucial mediators of fracture, were not found to be directly predisposing fracture. These findings postulate that interventions aimed at increasing bone and muscle strength are more likely to be successful in preventing fractures than widespread supplementation of vitamin D or other risk factors not mediating the disease process.