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Abstract
Several previous studies have shown that clinically diagnosed hearing loss is associated with changes in brain volume in regions supporting auditory and cognitive processing. The results of the present study based on data from 8701 participants in the UK Biobank resource representing a large middle-aged non-clinical population show that poorer hearing ability is associated with lower brain volume globally as well as in auditory and cognitive processing regions. There was no conclusive evidence that hearing aid use influenced these associations.