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Coffee consumption and cigarette smoking are strongly associated, but whether this association is causal remains unclear. We investigated whether coffee consumption increasing genetic variants were associated with cigarette consumption in publicly available GWAS data and UK Biobank. We followed up findings with laboratory research. Despite some evidence from publicly available GWAS data that coffee consumption might decrease cigarette smoking, these findings were not replicated in UK Biobank and were not supported by laboratory data. There is no clear evidence to suggest that coffee consumption influences smoking behaviour.