| Title: | The effect of smoking intensity on all-cause and cause-specific mortality-a Mendelian randomization analysis |
| Journal: | Int J Epidemiol |
| Published: | 1 Oct 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31074779/ |
| DOI: | https://doi.org/10.1093/ije/dyz081 |
Publication 2824
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
We used individual level data from the UK Biobank in a Mendelian randomisation framework to study the association between smoking intensity and specific causes of mortality. This data was meta-analysed with the Norwegian HUNT2 study. We found evidence to suggest that each effect allele of the rs1051730 (a genetic variant associated with smoking intensity) was associated with a 9% increased hazard of all-cause mortality (95% confidence interval 6-11%) among ever smokers. Effect alleles were also associated with death by neoplasms (HR 1.11, 95% CI 1.06-1.15), circulatory diseases (HR 1.06, 95% CI 1.01-1.11), and respiratory diseases (HR 1.15, 95% CI 1.05-1.26) among ever smokers.1 Author
- Vie GÅ et al.
1 Application
| Application ID | Title |
|---|---|
| 9142 | Using Mendelian Randomisation to investigate the causal effects of caffeine and smoking on health outcomes. |
Enabling scientific discoveries that improve human health