| Title: | Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances |
| Journal: | Elife |
| Published: | 15 Jan 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30642433/ |
| DOI: | https://doi.org/10.7554/eLife.39856 |
Publication 2895
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Abstract
Timmers et al. used genetic data from UK Biobank and other European cohorts alongside information on their parents lifespans to pinpoint DNA regions that influence how long people live. They identified 12 such regions, of which five were new and had not been linked to lifespan before. Across the twelve as a whole several were known to be involved in Alzheimer s disease, smoking-related cancer or heart disease. Looking at the entire genome, Timmers et al. could then predict a lifespan score for each individual, and when they sorted participants into ten groups based on these scores, they found that top group lived five years longer than the bottom, on average.1 Author
- Timmers PR et al.
1 Application
| Application ID | Title |
|---|---|
| 8304 | Genetics of human lifespan ? heritability, association and prediction |
Enabling scientific discoveries that improve human health