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The world s largest GWAS of osteoporosis involving ~142,000 subjects with genome-wide genotyping and quantitative ultrasound derived bone mineral density (i.e. a predictor of osteoporosis susceptability) . Identified 153 novel loci, screened 120 candidate genes using phenotyped KO mice, and implicated candidate gene GPC6 as a promising new drug target for osteoporosis. Awarded prestigious presentations at American Society of Bone Mineral Research and American Society of Human Genetics in 2016. Received considerable interest, with 17 global media reports, several media interviews (estimated audience 2.5M) and has already scored in the top 5% of all research outputs (Altmetric).