| Title: | Associations between Alzheimer's disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participants |
| Journal: | Neurobiology of Aging |
| Published: | 6 Nov 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33259984/ |
| DOI: | https://doi.org/10.1016/j.neurobiolaging.2020.11.002 |
| URL: | https://www.sciencedirect.com/science/article/pii/S0197458020303493 |
| Citations: | 25 (9 in last 2 years) as of 8 Aug 2024 |
Publication 3400
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Hippocampal volume is an important biomarker of Alzheimer's disease (AD), and genetic risk of AD is associated with hippocampal atrophy. However, the hippocampus is not a uniform structure and has a number of subfields, the associations of which with age, sex, and polygenic risk score for AD (PRSAD) have been inadequately investigated. We examined these associations in 17,161 cognitively normal UK Biobank participants (44-80 years). Age was negatively associated with all the hippocampal subfield volumes and females had smaller volumes than men. Higher PRSAD was associated with lower volumes in the bilateral whole hippocampus, hippocampal-amygdala-transition-area, and hippocampal tail; right subiculum; left cornu ammonis 1, cornu ammonis 4, molecular layer, and granule cell layer of dentate gyrus. Older individuals (median age 63 years, n = 8984) showed greater subfield vulnerability to high PRSAD compared to the younger group (n = 8177), but the effect did not differ by sex. The pattern of subfield involvement in relation to the PRSAD in community dwelling healthy individuals sheds additional light on the pathogenesis of AD.</p>
17 Keywords
- Adult
- Aged
- Aged, 80 and over
- Aging
- Alzheimer Disease
- Biological Specimen Banks
- Female
- Genetic Association Studies
- Hippocampus
- Humans
- Independent Living
- Male
- Middle Aged
- Multifactorial Inheritance
- Organ Size
- Risk
- United Kingdom
7 Authors
- Heidi Foo
- Anbupalam Thalamuthu
- Jiyang Jiang
- Forrest Koch
- Karen A Mather
- Wei Wen
- Perminder S Sachdev
1 Application
| Application ID | Title |
|---|---|
| 37103 | Risk Factors and Health Consequences of Cerebral White Matter Hyperintensity |
Enabling scientific discoveries that improve human health