| Title: | Oestradiol and the risk of myocardial infarction in women: a cohort study of UK Biobank participants |
| Journal: | International Journal of Epidemiology |
| Published: | 17 Jan 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33734370/ |
| DOI: | https://doi.org/10.1093/ije/dyaa284 |
| URL: | https://academic.oup.com/ije/article-pdf/50/4/1241/40146638/dyaa284.pdf |
| Citations: | 12 (7 in last 2 years) as of 8 Aug 2024 |
Publication 3543
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Abstract
BACKGROUND: It is commonly assumed that high oestradiol levels in women are cardioprotective. We assessed the association between oestradiol and the risk of incident myocardial infarction (MI) in women.</p>
METHODS: We used data from 263 295 female UK Biobank participants [mean age 56.2; standard deviation (SD) 8.0 years] without previous cardiovascular disease (CVD). Associations of oestradiol with age and other cardiovascular risk factors were assessed. Cox proportional hazards models estimated crude, ag- and multiple-adjusted hazard ratios (HR) for MI associated with oestradiol levels.</p>
RESULTS: After a mean follow-up of 9 years, 2206 incident cases of MI had been recorded, including 230 events among the 57 204 women (mean age 48) with detectable oestradiol levels. In the unadjusted analyses, a unit higher in log-transformed oestradiol was associated with an HR [95% confidence interval (CI) for MI of 0.73 (0.58; 0.92)]. After adjusting for age, this HR became 0.94 (0.75; 1.17), and after further adjusting for classical CVD risk factors, it was 1.05 (0.83; 1.31. Results were similar in subgroup analyses defined by age, menopausal status, socioeconomic status, contraceptive pill use and the use of hormone replacement therapy. The multivariable-adjusted HR for the 171 431 women (mean age 59) with undetectable levels of oestradiol, compared with those with detectable levels, was 0.97 (0.92; 1.02).</p>
CONCLUSIONS: Higher levels of oestradiol were not associated with a decreased risk of MI. The presumed cardioprotective effects of oestradiol seem to be largely confounded by age and further confounded by other cardiovascular risk factors.</p>
12 Keywords
- Biological Specimen Banks
- Cardiovascular Diseases
- Cohort Studies
- Estradiol
- Female
- Humans
- Incidence
- Middle Aged
- Myocardial Infarction
- Proportional Hazards Models
- Risk Factors
- United Kingdom
2 Authors
- Sanne A E Peters
- Mark Woodward
1 Application
| Application ID | Title |
|---|---|
| 2495 | Sex differences in the association between major and modifiable risk factors with cardiovascular disease |
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