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Abstract
Using Mendelian randomization, our study suggests that haemoglobin (HGB) is the key red blood cell trait causing venous thromboembolism (VTE). Given men have higher HGB than women, this finding may help explain the sexual disparity in VTE rates. The benefits of therapies and other factors that raise HGB need to be weighed against their risks.
Evaluation of the causal relation between hematocrit, hemoglobin, HbA1c, testosterone and cardiovascular outcomes in the UK Biobank using Mendelian randomization analysis