| Title: | Diabetes, Glycated Hemoglobin, and Risk of Cancer in the UK Biobank Study |
| Journal: | Cancer Epidemiol Biomarkers Prev |
| Published: | 1 Jun 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32179703/ |
| DOI: | https://doi.org/10.1158/1055-9965.EPI-19-1623 |
Publication 3683
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
The study examined the association between diabetes, HbA1c, and cancer risk in the UK Biobank, using data from 476,517 participants (54% women), followed for an average period of 7.1 years. Diabetes was defined on the basis of baseline self-reported diagnosis of diabetes and/or use of diabetes medication, while HbA1c measured at baseline was categorized as low (<31 mmol/mol), normal (31-<39 mmol/mol), increased risk (39-<48 mmol/mol), and high risk for diabetes (≥48 mmol/mol). Multivariable Cox proportional hazards models were used to estimate the association of diabetes and cancer at different anatomical sites, with adjustment for cancer-specific risk factors.The study found that diabetes was associated with increased risk of cancers of the stomach, liver, bladder, endometrium, and lung among smokers, and with decreased risk of prostate cancer. Compared with the normal HbA1c category, the increased risk category was positively associated with risk of cancers of the colon, liver, bladder, and lung among smokers, and the high-risk category was associated with increased risk of cancers of the esophagus, liver, pancreas, and bladder, and with decreased risk of prostate cancer. Based on the study results the authors suggested that both diabetes and/or elevated HbA1c are associated with risk of cancer at several anatomic sites.
1 Author
- Peila R et al.
1 Application
| Application ID | Title |
|---|---|
| 40086 | The association of type 2 diabetes and HbA1c with subsequent risk of cancer at different anatomical sites |
Enabling scientific discoveries that improve human health