| Title: | Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in a Large Cohort: Results From the UK Biobank |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 4 Jul 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32620963/ |
| DOI: | https://doi.org/10.1210/clinem/dgaa432 |
| URL: | https://academic.oup.com/jcem/article-pdf/105/10/e3606/41828220/dgaa432.pdf |
| Citations: | 67 (25 in last 2 years) as of 8 Aug 2024 |
Publication 3736
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Abstract
CONTEXT: Although an inverse association between vitamin D status and mortality has been reported in observational studies, the precise association shape and optimal vitamin D status remain undetermined.</p>
OBJECTIVE: To investigate the association between vitamin D status and risk of all-cause and cause-specific mortality and estimate optimal serum 25-hydroxyvitamin D [25(OH)D] concentrations.</p>
DESIGN: Prospective cohort study.</p>
SETTING: UK Biobank.</p>
PARTICIPANTS: 365 530 participants who had serum 25(OH)D measurements and no history of cardiovascular disease (CVD), cancer, or diabetes at baseline (2006-2010).</p>
MAIN OUTCOME MEASURES: All-cause and cause-specific mortality.</p>
RESULTS: During a median follow-up of 8.9 (interquartile range: 8.3-9.5) years, 10 175 deaths occurred, including 1841 (18.1%) due to CVD and 5737 (56.4%) due to cancer. The multivariate analyses revealed nonlinear inverse associations, with a decrease in mortality risk appearing to level off at 60 nmol/L of 25(OH)D for all-cause and CVD deaths and at 45 nmol/L for cancer deaths. Compared to participants with 25(OH)D concentrations below the cutoffs, those with higher concentrations had a 17% lower risk for all-cause mortality (hazard ratio [HR]: 0.83, 95% confidence interval [CI]: 0.79-0.86), 23% lower risk for CVD mortality (HR: 0.77, 95% CI: 0.68-0.86), and 11% lower risk for cancer mortality (HR: 0.89, 95% CI: 0.84-0.95).</p>
CONCLUSIONS: Higher 25(OH)D concentrations are nonlinearly associated with lower risk of all-cause, CVD, and cancer mortality. The thresholds of 45 to 60 nmol/L might represent an intervention target to reduce the overall risk of premature death, which needs further confirmation in large clinical trials.</p>
9 Authors
- Xikang Fan
- Jiayu Wang
- Mingyang Song
- Edward L Giovannucci
- Hongxia Ma
- Guangfu Jin
- Zhibin Hu
- Hongbing Shen
- Dong Hang
1 Application
| Application ID | Title |
|---|---|
| 52217 | Serum cardiometabolic biomarkers in relation to all-cause and cause-specific mortality |
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