| Title: | Association between TV viewing and heart disease mortality: observational study using negative control outcome |
| Journal: | Journal of Epidemiology & Community Health |
| Published: | 20 Jan 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31959721/ |
| DOI: | https://doi.org/10.1136/jech-2019-212739 |
| URL: | ~Ehttps://discovery.ucl.ac.uk/10090327/3/Hamer_Association%20between%20TV%20viewing%20and%20heart%20disease%20mortality.%20Observational%20study%20using%20negative%20control%20outcome_AAM.pdf~ |
Publication 4167
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Abstract
AIMS: Sedentary behaviour (particularly television (TV) viewing) is thought to be a risk factor for cardiovascular disease. We employed a negative control outcome to explore whether the association between TV viewing and heart disease mortality is explained by confounding.</p>
METHODS: The sample was drawn from the UK Biobank study and comprised 479 658 participants (aged 56.5±8.0 years; 45.7% men) followed up over a mean of 10.4 years. TV viewing was measured from self-report.</p>
RESULTS: There were 1437 ischaemic heart disease (IHD) deaths, and 214 accidental deaths (employed as the negative control outcome). TV viewing was related to the following confounding variables: age, smoking, alcohol, diet, obesity, physical inactivity, cardiovascular disease and education. The confounding structures were similar for both outcomes. TV viewing (per hour/d) was associated with IHD (hazard ratio (HR)=1.30, 95% CI, 1.27 to 1.33) and accidental death (HR=1.15, 95% CI, 1.07 to 1.24) in unadjusted models. Associations were attenuated for both outcomes and were considerably converged after adjustment for confounders; IHD (HR=1.09, 95% CI, 1.06 to 1.12) and accidental death (HR=1.06, 95% CI, 0.98 to 1.15).</p>
CONCLUSION: The pattern of results for TV with an implausible outcome mirrored that of IHD, suggesting that observed associations between TV and heart disease are likely to be driven by confounding.</p>
15 Keywords
- Adult
- Aged
- Cardiovascular Diseases
- Cause of Death
- Cohort Studies
- Diet
- Exercise
- Female
- Humans
- Male
- Middle Aged
- Motor Activity
- Risk Factors
- Sedentary Behavior
- Television
5 Authors
- Mark Hamer
- Ding Ding
- Josephine Chau
- Mitch J Duncan
- Emmanuel Stamatakis
1 Application
| Application ID | Title |
|---|---|
| 25813 | Integrated paradigms to investigate the interplay between lifestyle behaviours, the social environment, and genetic risk in the development of cardio- metabolic disease and mental health. |
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