| Title: | Causal effects of gallstone disease on risk of gastrointestinal cancer in Chinese |
| Journal: | British Journal of Cancer |
| Published: | 26 Mar 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33772150/ |
| DOI: | https://doi.org/10.1038/s41416-021-01325-w |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144569 |
Publication 4442
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Abstract
BackgroundGallstone disease (GSD) is associated with a higher risk of gastrointestinal (GI) cancer. However, it is unclear whether the associations are causal.MethodsThe prospective China Kadoorie Biobank (CKB) recorded 17,598 cases of GI cancer among 510,137 participants without cancer at baseline during 10 years of follow-up. Cox regression was used to estimate hazard ratios (HRs) for specific cancer by GSD status and duration. Mendelian randomisation was conducted to assess the genetic associations of GSD with specific cancer.ResultsOverall 6% of participants had symptomatic GSD at baseline. Compared with those without GSD, individuals with symptomatic GSD had adjusted HRs of 1.13 (1.01-1.29) for colorectal, 2.01 (1.78-2.26) for liver, 3.70 (2.88-4.87) for gallbladder, 2.31 (1.78-3.07) for biliary tract, and 1.38 (1.18-1.74) for pancreatic cancer. Compared with participants without GSD, the risks of colorectal, liver, gallbladder, biliary tract, and pancreatic cancer were highest during 0 to <5 years following disease diagnosis. There was evidence of genetic associations of GSD with these cancers, with odds ratios per 1-SD genetic score of 1.08 (1.05-1.11) for colorectal, 1.22 (1.19-1.25) for liver, 1.56 (1.49-1.64) for gallbladder, 1.39 (1.31-1.46) for biliary tract, and 1.16 (1.10-1.22) for pancreatic cancer. When meta-analysing the genetic estimates in CKB and UK Biobank, there was evidence of causal associations of GSD with colon cancer, gallbladder and biliary tract cancer (GBTC), and total GI cancer (RR per 1-SD: 1.05 [0.99-1.11], 2.00 [1.91-2.09], and 1.09 [1.05-1.13]).ConclusionsGSD was associated with higher risks of several GI cancers, warranting future studies on the underlying mechanisms.</p>
16 Authors
- Yuanjie Pang
- Jun Lv
- Christiana Kartsonaki
- Yu Guo
- Canqing Yu
- Yiping Chen
- Ling Yang
- Zheng Bian
- Iona Y. Millwood
- Robin G. Walters
- Xiaojun Li
- Ju Zou
- Michael V. Holmes
- Junshi Chen
- Zhengming Chen
- Liming Li
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