| Title: | Large-scale whole-exome sequencing association study identifies FOXH1 gene and sphingolipid metabolism pathway influencing major depressive disorder |
| Journal: | CNS Neuroscience & Therapeutics |
| Published: | 11 Oct 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34633764/ |
| DOI: | https://doi.org/10.1111/cns.13733 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.13733 |
Publication 5310
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Abstract
In the present study, we performed an exome-wide investigation of the burden of rare disease-causing variants for major depressive disorder (MDD) using 16,702 samples from UK biobank. Gene-based association analysis and candidate gene prioritization analysis indicated that FOXH1 have significant association with MDD. In addition, sphingolipid metabolism pathway was found to be less enriched with rare disease-causing variants in the MDD group, suggesting that this gene set may be involved in the pathophysiology of MDD.9 Authors
- Wei Zhou
- Luan Chen
- Bixuan Jiang
- Yidan Sun
- Mo Li
- Hao Wu
- Na Zhang
- Xiaofang Sun
- Shengying Qin
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