| Title: | Neuroticism and Risk of Parkinson's Disease: A Meta-Analysis |
| Journal: | Movement Disorders |
| Published: | 4 Apr 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33817817/ |
| DOI: | https://doi.org/10.1002/mds.28575 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376751 |
Publication 5455
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Neuroticism is linked to mood disorders and Alzheimer's disease, but fewer studies have tested the prospective association with Parkinson's disease (PD).</p>
OBJECTIVES: To examine the association between neuroticism and risk of PD in a large cohort and a meta-analysis of prospective cohort studies.</p>
METHODS: Participants from the UK Biobank (N = 490,755) completed a neuroticism scale in 2006-2010. Incident PD was ascertained using electronic health records or death records up to 2018. The systematic search and meta-analysis followed the MOOSE guidelines.</p>
RESULTS: During 11.91 years of follow-up (mean = 8.88 years; 4,360,105 person-years) 1142 incident PD cases were identified. Neuroticism was associated with higher risk of incident PD, both as continuous (HR = 1.28; 95% CI: 1.21-1.36) and categorical variable (top vs. bottom quartiles: HR = 1.88; 95% CI: 1.60-2.22). The association remained significant after accounting for age, sex, smoking, physical activity, anxiety, and depressed mood, and after excluding cases that occurred within the first 5 years of follow-up. The associations were similar for women and men and across levels of socioeconomic status. Random-effect meta-analysis of four prospective studies (N = 548,284) found neuroticism associated with increased risk of incident PD (HR = 1.82; 95% CI: 1.59-2.08; P = 7.31-19 ). There was no evidence of heterogeneity across studies with follow-ups ranging from one to four decades.</p>
CONCLUSION: The results from the large UK Biobank and meta-analysis of prospective studies indicate that neuroticism is consistently associated with a higher risk of incident PD. © 2021 International Parkinson and Movement Disorder Society.</p>
7 Keywords
- Alzheimer Disease
- Cohort Studies
- Humans
- Neuroticism
- Parkinson Disease
- Prospective Studies
- Risk Factors
7 Authors
- Antonio Terracciano
- Damaris Aschwanden
- Yannick Stephan
- Antonio Cerasa
- Luca Passamonti
- Nicola Toschi
- Angelina R. Sutin
1 Application
| Application ID | Title |
|---|---|
| 57672 | Linking psychological well-being measures to brain and health biomarkers to understand aging and risk of dementia |
Enabling scientific discoveries that improve human health