| Title: | Reserve and Alzheimer's disease genetic risk: Effects on hospitalization and mortality |
| Journal: | Alzheimer's & Dementia |
| Published: | 1 Jul 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31327391/ |
| DOI: | https://doi.org/10.1016/j.jalz.2019.04.005 |
| URL: | https://europepmc.org/articles/pmc7049165?pdf=render |
Publication 5672
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Abstract
INTRODUCTION: Cognitive reserve predicts delayed diagnosis of Alzheimer's disease (AD) and faster postdiagnosis decline. The net impact of cognitive reserve, combining both prediagnosis and postdiagnosis risk, on adverse AD-related outcomes is unknown. We adopted a novel approach, using AD genetic risk scores (AD-GRS), to evaluate this.</p>
METHODS: Using 242,959 UK Biobank participants age 56+ years, we evaluated whether cognitive reserve (operationalized as education) modified associations between AD-GRS and mortality or hospitalization (total count, fall-related, and urinary tract infection-related).</p>
RESULTS: AD-GRS predicted mortality and hospitalization outcomes. Education did not modify AD-GRS effects on mortality, but had a nonsignificantly (interaction P = .10) worse effect on hospitalizations due to urinary tract infection or falls among low education (OR = 1.07 [95% CI: 1.02, 1.12]) than high education (OR = 1.01 [0.95, 1.07]) individuals.</p>
DISCUSSION: Education did not convey differential survival advantages to individuals with higher genetic risk of AD, but may reduce hospitalization risk associated with AD genetic risk.</p>
13 Keywords
- Alzheimer Disease
- Cognitive Reserve
- Cohort Studies
- Female
- Genetic Predisposition to Disease
- Hospitalization
- Humans
- Male
- Middle Aged
- Mortality
- Polymorphism, Single Nucleotide
- Risk Factors
- United Kingdom
8 Authors
- Teresa Jenica Filshtein
- Willa D. Brenowitz
- Elizabeth Rose Mayeda
- Timothy J. Hohman
- Stefan Walter
- Rich N. Jones
- Fanny M. Elahi
- M. Maria Glymour
1 Application
| Application ID | Title |
|---|---|
| 34507 | The inverse link between incidence rates of cancer and Alzheimer's disease: comparing spurious and causal explanations to illuminate the causes of Alzheimer's disease. |
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