| Title: | Testing for Interactions Between APOE and Klotho Genotypes on Cognitive, Dementia, and Brain Imaging Metrics in UK Biobank |
| Journal: | Journal of Alzheimer's Disease |
| Published: | 31 Aug 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34219715/ |
| DOI: | https://doi.org/10.3233/jad-210181 |
| URL: | https://eprints.gla.ac.uk/244268/2/244268.pdf |
| Citations: | 6 (6 in last 2 years) as of 8 Aug 2024 |
Publication 5801
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Abstract
Recent research suggests genetic variation in the Klotho locus may modify the association between APOE ɛ4 and cognitive impairment. We tested for associations and interactions between these genotypes versus risk of dementia, cognitive abilities, and brain structure in older UK Biobank participants. Klotho status was indexed with rs9536314 heterozygosity (versus not), in unrelated people with versus without APOE ɛ4 genotype, corrected for various confounders. APOE ɛ4 associated with increased risk of dementia, worse cognitive abilities, and brain structure. Klotho was associated with better reasoning. There were no interactions; potentially suggesting an age- and pathology-dependent Klotho effect.</p>
17 Keywords
- Apolipoprotein E4
- Biological Specimen Banks
- Brain
- Cognitive Dysfunction
- Dementia
- Female
- Genotype
- Glucuronidase
- Heterozygote
- Humans
- Klotho Proteins
- Male
- Middle Aged
- Mutation
- Neuroimaging
- Prospective Studies
- United Kingdom
6 Authors
- Rachana Tank
- Joey Ward
- Carlos Celis-Morales
- Daniel J. Smith
- Kristin E. Flegal
- Donald M. Lyall
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