| Title: | Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk |
| Journal: | Nature Genetics |
| Published: | 30 Jan 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28135244/ |
| DOI: | https://doi.org/10.1038/ng.3768 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972004 |
| Citations: | 498 (97 in last 2 years) as of 8 Aug 2024 |
Publication 585
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Mark Caulfield, Paul Elliott and colleagues use data from the UK Biobank to perform genome-wide association analysis for blood pressure traits. They identify and validate 107 novel loci and highlight new biological pathways for potential therapeutic intervention for hypertension.</p>
14 Keywords
- Adult
- Blood Pressure
- Cardiovascular Diseases
- Female
- Genetic Loci
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Hypertension
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Risk Factors
- White People
59 Authors
- Helen R Warren
- Evangelos Evangelou
- Claudia P Cabrera
- He Gao
- Meixia Ren
- Borbala Mifsud
- Ioanna Ntalla
- Praveen Surendran
- Chunyu Liu
- James P Cook
- Aldi T Kraja
- Fotios Drenos
- Marie Loh
- Niek Verweij
- Jonathan Marten
- Ibrahim Karaman
- Marcelo P Segura Lepe
- Paul F O'Reilly
- Joanne Knight
- Harold Snieder
- Norihiro Kato
- Jiang He
- E Shyong Tai
- M Abdullah Said
- David Porteous
- Maris Alver
- Neil Poulter
- Martin Farrall
- Ron T Gansevoort
- Sandosh Padmanabhan
- Reedik Mägi
- Alice Stanton
- John Connell
- Stephan J L Bakker
- Andres Metspalu
- Denis C Shields
- Simon Thom
- Morris Brown
- Peter Sever
- Tõnu Esko
- Caroline Hayward
- Pim van der Harst
- Danish Saleheen
- Rajiv Chowdhury
- John C Chambers
- Daniel I Chasman
- Aravinda Chakravarti
- Christopher Newton-Cheh
- Cecilia M Lindgren
- Daniel Levy
- Jaspal S Kooner
- Bernard Keavney
- Maciej Tomaszewski
- Nilesh J Samani
- Joanna M M Howson
- Martin D Tobin
- Patricia B Munroe
- Georg B Ehret
- Louise V Wain
1 Application
| Application ID | Title |
|---|---|
| 236 | Genome-wide association study of blood pressure. |
Enabling scientific discoveries that improve human health