WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
This research seeks to use the medical, cognitive, imaging and genetic data from UKBiobank to study the mechanisms of common medical conditions and use them as a platform to better diagnosis. Stratifying depression into more homogenous categories will provide better 'disease' targets for other research studies because there will be less lumping together of individuals with different causes for their illness within the same broad category of depression.
We performed a genome-wide association study (GWAS) of self-reported alcohol consumption in 112,117 individuals in the UK Biobank (UKB) sample of white British individuals. We report significant genome-wide associations at 13 loci. These include SNPs in alcohol metabolizing genes (ADH1B/ADH1C/ADH5) and 2 loci in KLB, a gene recently associated with alcohol consumption. We also identify SNPs at novel loci including GCKR, CADM2 and FAM69C.
T K Clarke, et al. Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N =112 117). Molecular Psychiatry (2017) 22, 1376 1384 doi:10.1038/mp.2017.153