| Title: | Fast and accurate long-range phasing in a UK Biobank cohort |
| Journal: | Nature Genetics |
| Published: | 6 Jun 2016 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/27270109/ |
| DOI: | https://doi.org/10.1038/ng.3571 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925291 |
| Citations: | 305 (65 in last 2 years) as of 8 Aug 2024 |
Publication 7549
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Abstract
Po-Ru Loh, Pier Francesco Palamara and Alkes Price develop a new long-range phasing method, Eagle, that harnesses long, shared identical-by-descent tracts and can be applied to large outbred populations. They use Eagle to phase samples from the UK Biobank and find that it is faster and has better accuracy than existing methods.</p>
14 Keywords
- Algorithms
- Biological Specimen Banks
- Cohort Studies
- Computational Biology
- Genetics, Population
- Genome, Human
- Genomics
- High-Throughput Nucleotide Sequencing
- Humans
- Inheritance Patterns
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA
- United Kingdom
- White People
3 Authors
- Po-Ru Loh
- Pier Francesco Palamara
- Alkes L Price
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