| Title: | A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization |
| Journal: | Nature Communications |
| Published: | 11 Jan 2021 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33431812/ |
| DOI: | https://doi.org/10.1038/s41467-020-20368-w |
| URL: | https://www.nature.com/articles/s41467-020-20368-w.pdf |
Publication 9534
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Abstract
Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants and found no relationship between 25(OH)D and cancer; however, issues of horizontal pleiotropy cannot be reliably addressed. Using a larger set of variants associated with 25(OH)D (74 SNPs, up from 6 previously), we perform a unified MR analysis to re-evaluate the relationship between 25(OH)D and ten cancers. Our findings are broadly consistent with previous MR studies indicating no relationship, apart from ovarian cancers (OR 0.89; 95% C.I: 0.82 to 0.96 per 1 SD change in 25(OH)D concentration) and basal cell carcinoma (OR 1.16; 95% C.I.: 1.04 to 1.28). However, after adjustment for pigmentation related variables in a multivariable MR framework, the BCC findings were attenuated. Here we report that lower 25(OH)D is unlikely to be a causal risk factor for most cancers, with our study providing more precise confidence intervals than previously possible.</p>
24 Authors
- Jue-Sheng Ong
- Suzanne C. Dixon-Suen
- Xikun Han
- Jiyuan An
- Upekha Liyanage
- Jean-Cluade Dusingize
- Johannes Schumacher
- Ines Gockel
- Anne Böhmer
- Janusz Jankowski
- Claire Palles
- Tracy O'Mara
- Amanda Spurdle
- Matthew H. Law
- Mark M. Iles
- Paul Pharoah
- Andrew Berchuck
- Wei Zheng
- Aaron P. Thrift
- Catherine Olsen
- Rachel E. Neale
- Puya Gharahkhani
- Penelope M. Webb
- Stuart MacGregor
1 Application
| Application ID | Title |
|---|---|
| 25331 | Gene mapping and genetic correlation across complex traits |
Enabling scientific discoveries that improve human health