| Title: | Systematic Analysis of Human Immunity Functional Decline During Aging |
| Lead Institution: | Peking University |
| Principal investigator: |
Application 141269
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About
Our research project seeks to understand how the immune system evolves as we age and how these changes impact our health. Aging is a natural process, but it often comes with increased vulnerability to diseases and infections. We aim to uncover the reasons behind these age-related immune changes and discover ways to maintain strong immune defenses as we grow older. As we age, our immune system undergoes intricate changes, affecting its ability to protect us from diseases. These changes are not yet fully understood, and their connections to age-related diseases remain elusive. Our research harnesses a wide range of data, including medical records, genetic information, and lifestyle details, to piece together the puzzle of immune aging. By analyzing this data, we hope to identify patterns and clues that shed light on how our immune systems change over time and the implications for our overall health. This research project will span several years, allowing us to collect and analyze more data from a diverse group of people. This extended timeline ensures that we can track changes in the immune system over time comprehensively and gain a deeper understanding of the aging process. The public health impact of this research is significant. Understanding immune aging holds the potential to inform strategies for healthier aging and reducing the risk of age-related diseases. It could pave the way for personalized healthcare approaches, where treatments and interventions are tailored to an individual's unique immune profile. Ultimately, our goal is to improve the quality of life for older individuals and alleviate the burden of healthcare costs associated with age-related illnesses.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 17900 | A generative AI framework unifies human multi-omics to model aging, metabolic health, and intervention response | Jiawei Chen (+14) | 2026 | Cell Metabolism |
Enabling scientific discoveries that improve human health