| Title: | Association of multiple environmental exposures and non-environmental factors with cancer incidence and mortality |
| Lead Institution: | The First Hospital of China Medical University |
| Principal investigator: |
Application 226023
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About
Cancer is emerging as a major public health challenge globally and also a complex and multifactorial disease. The acute impact of climate change on human health is receiving increased attention, but little is known or appreciated about the effect of climate change on chronic diseases, particularly cancer. Epidemiological studies over the past two decades have provided strong evidence that environmental components interacting with lifestyle factors can individually and collectively influence the occurrence of cancer. However, prior research has largely focused on studying exposures to one contaminant at one time, which does not reflect the real-world environment. In addition, few studies have investigated the combined and synergistic effects of environmental exposure and non-environmental factors on incidence and mortality of different cancers. The present study aimed to assess the associations of multiple environmental exposures (e.g. residential air pollution, residential noise pollution, and greenspace) and non-environmental factors (e.g. modifiable lifestyle factors, biochemical markers, medication use, early life factors, and comorbidities) with incidence and mortality of different cancers (e.g. breast cancer, ovarian cancer, cervical cancer, gastric cancer, and liver cancer) and to investigated the combined and synergistic effects of environmental exposure and non-environmental factors on incidence and mortality of different cancers. This project has important implications for improving health status and developing strategies to prevent cancers.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 12925 | RETRACTED ARTICLE: Association of Life's Essential 8 cardiovascular health with breast cancer incidence and mortality according to genetic susceptibility of breast cancer: a prospective cohort study | Yan Zhao (+3) | 2024 | Breast Cancer Research |
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