| Title: | Air pollution, immunohematologic failure, and cardiovascular risk |
| Lead Institution: | University Hospitals Cleveland Medical Center |
| Principal investigator: | Dr Sadeer Al-Kindi |
Application 61548
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About
Aim: The aim of this proposal is to understand the impact of non-traditional factors (immune dysfunction, air pollution, and socioeconomic status) on risk of heart disease. Scientific Rationale: Air pollution and socioeconomic status have been individually associated with risk of heart disease. We have shown that dysfunction of the immune system (reflected by reduced number of lymphocytes) and the red blood cell system (as measured by high variability in red cell size) are associated with risk of death from heart disease Project Duration: The duration of this project is approximately 3 years Public Health Impact: Understanding non-traditional risk factors of heart disease will help identify high-risk populations, for whom intensive cardiovascular risk reduction can be investigated.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 20828 | Interaction between air pollution and genetic predisposition to blood pressure and low-density lipoprotein cholesterol on cardiovascular events | Jean-Eudes Dazard (+15) | 2026 | European Journal of Preventive Cardiology |
Enabling scientific discoveries that improve human health