| Title: | LEAP-CKD: Lifestyle, Environment And Physiology: an exploration of the association with future chronic kidney disease |
| Lead Institution: | University of Glasgow |
| Principal investigator: | Dr Elaine Rutherford |
Application 69891
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About
Chronic kidney disease (CKD) is an important public health problem associated with around 20-30,000 excess deaths each year within England. 15% of women over the age of 65 have CKD. Women are more likely to develop CKD in later life than men. This research aims to explore reasons for this difference including lifestyle factors and whether or not having children impacts upon future risk of developing CKD. Factors such as physical activity, diet and socio-economic background are likely to influence a person's risk of developing CKD. We know that certain 'healthy' choices are associated with reduced risk of developing CKD; we do not know if these factors also affect progression of CKD. In CKD 'healthy' diets are often difficult to achieve and advice may be given to restrict healthy foods like fruit and vegetables. Additionally lifestyle factors associated with being a parent (or not) may also impact on a person's risk of CKD. We will explore the role of lifestyle factors, which are important to both men and women, in the development and progression of CKD. This is an important public health issue as CKD is both a common and a serious illness, modification of lifestyle factors could be a simple way to reduce its impact. In women specifically, we do not know whether or not the changes a woman's body goes through as a result of becoming pregnant and delivering a child impact her future risk of CKD. During pregnancy blood flow to the kidneys increases by more than 50% and the filtering units of the kidney (glomeruli) filter 50% more blood and waste products. The kidneys change structure during pregnancy and become more swollen with water (hydronephrosis). Hormonal changes occur, including increased activity of the renin-angiotensin-aldosterone system which affects blood pressure and salt and water retention. Some pregnancy complications (eg high blood pressure) are associated with increased risk of future CKD but we don't know what effect the changes which occur during healthy pregnancy might have on a women's future health. It might be that the total number of pregnancies that a woman has, the age she is when she has children, the gap between pregnancies or whether she has multiple pregnancies influences her future CKD risk. Answering these questions should help to direct future research and enable women and men to make informed choices in the future. This project will take around 36 months to complete.4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 10529 | Assessment of Cystatin C Level for Risk Stratification in Adults With Chronic Kidney Disease | Jennifer S. Lees (+9) | 2022 | JAMA Network Open |
| 8816 | Cystatin C- and Creatinine-based Estimated GFR Differences: Prevalence and Predictors in the UK Biobank | Debbie C. Chen (+10) | 2024 | Kidney Medicine |
| 11006 | Differential Associations of Cystatin C Versus Creatinine-Based Kidney Function With Risks of Cardiovascular Event and Mortality Among South Asian Individuals in the UK Biobank | Debbie C. Chen (+8) | 2023 | Journal of the American Heart Association |
| 7834 | Sex differences in associations between creatinine and cystatin C-based kidney function measures with stroke and major bleeding | Jennifer Susan Lees (+9) | 2023 | European Stroke Journal |
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