| Title: | Glycosaminoglycan polymorphism x sodium interaction effect on blood pressure |
| Lead Institution: | Amsterdam UMC Research BV |
| Principal investigator: | Ms Jetta Oppelaar |
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About
High blood pressure is a worldwide major public health challenge due to its high prevalence and associated increased risk for cardiovascular diseases such as renal failure and heart attacks. Blood pressure is a complex trait which is determined by both genetic and environmental factors as well as their mutual interactions. A lot of research has been done into the genetic origin of blood pressure regulation. These studies have identified many important genes, however, still a small proportion of genetics behind blood pressure can be explained. High dietary sodium intake is an important environmental risk factor for the development of high blood pressure. Some genetic factors might increase the risk for high blood pressure during high dietary salt intake. In the last decades, glycosaminoglycans (large sugar molecules which are produced by all cells of our body) have been identified as sodium buffering compartment; meaning that they can bind sodium in high sodium conditions (for example after high dietary sodium intake). A correct functioning of sodium buffering by glycosaminoglycans is associated with blood pressure regulation. We hypothesize that genetic defects (single nucleotide polymorphisms) in genes related to glycosaminoglycans might interact with sodium intake on the regulation of blood pressure. In our study, we aim to identify such sodium-interacting genetic defects in glycosaminoglycan genes in order to better understand which genes attribute to high-sodium induced high blood pressure. When we are able to identify risk genetic defects, we can identify patients/persons ad risk or high sodium intake and we can personalize our advice regarding sodium intake in these patients.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 13514 | Genetic Variance in Heparan Sulfation Is Associated With Salt Sensitivity | Jetta J. Oppelaar (+9) | 2024 | Hypertension |
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