| Title: | The Impact of Gait Disturbance on Neuroimaging and Plasma Biomarkers of Alzheimer's Disease |
| Lead Institution: | Johns Hopkins University |
| Principal investigator: |
Application 760913
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About
Gait disturbance in Alzheimer's Disease (AD) was found to be a significant predictor of more rapid progression to severe cognitive impairment. However, little is known about the mechanism behind which gait dysfunction contributes to more rapid AD progression. Preliminary research suggests that slower gait pace in AD is linked to widespread amyloid-! deposition (Del Campo et al., Kim et al.) and cortical atrophy (Kim et al.) in various brain regions, as well as levels of tau in the CSF (Muurling et al.). Limitations of existing studies include heterogeneity in imaging modalities, lack of mechanistic understanding behind which motor symptoms contribute to neuroimaging/biomarker changes, as well as limited longitudinal data assessing how changes in motor symptoms correlate with imaging correlates over time. With a cohort of clinically diagnosed mild cognitive impairment (MCI) and Alzheimer's Disease (AD) patients, we aim to: 1. To determine the relationship between patient-reported gait disturbance and plasma and neuroimaging biomarkers of Alzheimer's Disease 2. To determine whether other factors such as degree of physical activity or sedentariness moderate the impact of gait dysfunction on fluid and neuroimaging biomarkers 3. To assess the temporal relationship between gait dysfunction in AD and neuroimaging/fluid biomarkers Insight into the relationship between gait dysfunction and fluid and neuroimaging correlates of Alzheimer's Disease during life will provide a clearer mechanistic understanding of its influence on disease progression. Additionally, whether factors such as degree of physical activity moderate the impact of gait disturbance on biomarkers in AD will help to understand whether exercise may be used as an interventional strategies in these patients to prevent rapid clinical decline. Finally, more precise understanding of the impact of gait disturbance on neuroimaging may inform neuromodulatory strategies for this high risk population.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 20817 | Relationship between new-onset falls and neuroimaging markers of Alzheimer's disease in the UK Biobank. | Jacob S Shaw (+7) | 2026 | Journal of Alzheimer's Disease |
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