| Title: | Integrative Multi-Omic Profiling of Multidimensional Environmental, Social, and Behavioral Exposures and Their Impact on Population Health Outcomes |
| Lead Institution: | Southern Medical University |
| Principal investigator: |
Application 806778
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About
While substantial progress has been made in identifying genetic susceptibility loci, multi-domain exposures (encompassing environmental factors, sociodemographic determinants, lifestyle behaviors, and metabolic dysregulation), and population-level environmental drivers for chronic non-communicable diseases (NCDs) and associated mortality, critical gaps persist in understanding their molecular mediation mechanisms. Capitalizing on the UK Biobank's comprehensive multi-omics dataset integrating genomic profiles, longitudinal metabolomic measurements, and granular exposure assessments, this investigation proposes to: 1. Establish Metabolic Precursors of NCD Pathogenesis Conduct prospective analyses of baseline plasma metabolomes using multi-dimensional survival models to identify: Disease-specific metabolic signatures for six major NCD categories (hypertension, T2D, CVD, cancer, respiratory/digestive disorders, neurocognitive decline); Mortality-associated metabolic trajectories; 2. Delineate Multimorbidity Transition Pathways Develop system medicine frameworks to model: Temporal metabolic shifts during single-to-multi disease progression; Exposure-mediated acceleration of comorbidity networks; Composite risk signatures integrating longitudinal metabolomic fluxes with multi-omic profiles to inform precision prevention frameworks.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 17822 | Accelerometer-Derived 'Weekend Warrior' Physical Activity Pattern and Microvascular Risk in Individuals With Type 2 Diabetes and Prediabetes | Hao-Jie Chen (+16) | 2026 | Diabetes Obesity and Metabolism |
Enabling scientific discoveries that improve human health