| Title: | The epidemiology of liver disease in a population-based cohort. |
| Lead Institution: | University of Oxford |
| Principal investigator: | Hamish Innes |
Application 8764
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
This project aims to better understand the epidemiology of liver disease in a general population context. A particular focus will be paid to uncovering the risk factors associated with the new onset of liver disease. We intend to translate this knowledge into a prognostic model that predicts the near-term risk of new onset liver disease. The ultimate aim is to enable clinicians to identify individuals at high risk and intervene appropriately. Death from liver disease are rising in the UK, whilst it is falling in other European settings (Leon et al, 2006; Williams et al, 2014). We need to improve our understanding of the determinants of liver disease in order to thwart this worrying trend. Our intention to build an `early-warning` prognostic model would have direct clinical application, and is very much in keeping the the UK Biobank mission statement of `supporting a diverse range of research intended to improve the prevention, diagnosis and treatment of illness and the promotion of health throughout society` We will compare persons who do and do not go on to develop liver disease subsequent to their UK Biobank interview. Our aim is to try and tease out, what factors distinguishes these two groups. We will search for differences across an array of categories: in particular, alcohol consumption, genetic markers, social-demographic factors, and biochemistry markers. We intend then to use what we learn to build a risk prediction tool that informs individual patients of their near-term risk for liver failure. All participants5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 5024 | Genome-Wide Association Study for Alcohol-Related Cirrhosis Identifies Risk Loci in MARC1 and HNRNPUL1 | Hamish Innes (+30) | 2020 | Gastroenterology |
| 11004 | High producer variant of lipoprotein lipase may protect from hepatocellular carcinoma in alcohol-associated cirrhosis | Franziska Schmalz (+16) | 2023 | JHEP Reports |
| 12490 | Performance of routine risk scores for predicting cirrhosis-related morbidity in the community | Hamish Innes (+5) | 2022 | Journal of Hepatology |
| 12387 | The rs429358 Locus in Apolipoprotein E Is Associated With Hepatocellular Carcinoma in Patients With Cirrhosis | Hamish Innes (+37) | 2022 | Hepatology Communications |
| 10520 | The rs72613567:TA polymorphism in HSD17B13 is associated with survival benefit after development of hepatocellular carcinoma | Hamish Innes (+4) | 2023 | Alimentary Pharmacology & Therapeutics |
Enabling scientific discoveries that improve human health