274,953 items of data are available, covering 274,953 participants.
Defined-instances run from 0 to 0, labelled using Instancing 2
Units of measurement are litres.
- Mean = 2.90051
- Std.dev = 0.582169
Predicted Forced Expiratory Volume in 1-second (FEV1), was calculated using a subset of "healthy never smokers" from UK Biobank. "Healthy never smokers", were selected as individuals with "Ever Smoking Status"=0 and with "Reproducible measure using the European Respiratory Society/American Thoracic Society (ERS/ATS) Criteria"=YES (1), with the following exclusions:
- Field 2316: Individuals who indicated that they had experienced wheeze: "Yes" (1), "Do not know" (-1) or "Prefer not to answer" (-3).
- Field 6152: Individuals who reported "emphysema/chronic bronchitis" (6) or "asthma" (8) or "Prefer not to answer" (-3).
- Field 20002: Individuals who reported any of the following: asthma (1111), COPD (1112), emphysema/chronic bronchitis (1113), bronchiectasis (1114), interstitial lung disease (1115), asbestosis (1120), pulmonary fibrosis (1121), fibrosing/unspecified alveolitis (1122), respiratory failure (1124), pleurisy (1125), spontaneous/recurrent pneumothorax (1126), other respiratory problems (1117).
Healthy never smokers were grouped into 58 age-sex bands (29 age bands per sex; ages 39, 40 and 41 were grouped into one band and ages 69, 70 and 72 were grouped into one band with ages 42 to 68 each forming a separate band) and the following linear regression model was fitted in each age-sex band:
FEV1 = Beta0 + Beta1 * Standing Height
Predicted FEV1 was then calculated for all samples who were never smokers ("Ever Smoking Status"=0) or heavy smokers ("Ever Smoking Status"=1 AND "Pack years as proportion of life span exposed to smoking" >= 0.42) and with "Reproducible measure using the European Respiratory Society/American Thoracic Society (ERS/ATS) Criteria"=YES, using the estimates of Beta0 and Beta1, from the appropriate age-sex band:
Predicted FEV1= (pred.Beta0) + (pred.Beta1)^ * Standing Height
Five individuals were outliers in terms of their FEV1 and were not coded.
This derived data field has come from Professor Martin Tobin at the University of Leicester.
The current field was updated in 2021, using the regression method described above. Coverage was increased to include any participant who indicated at initial assessment (instance 0) that they either occasionally smoked, or where "Pack years as proportion of life span exposed to smoking" < 0.42.
The original research group additionally indicated that they now use GLI-2012 equations to produce predicted values for FEV1, details can be found at https://www.ers-education.org/guidelines/global-lung-function-initiative/faq/how-to-use-the-quanjer-gli-2012-equations.aspx.