| Title: | Regulators of the association between ocular disorders and systemic diseases. |
| Lead Institution: | Guangdong Provincial People's Hospital |
| Principal investigator: | Professor Honghua Yu |
Application 86091
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About
Aims: The overall goal of this project is to explore the regulators of the associations between ocular disorders and systemic diseases. Specific aims are: 1. To explore environmental factors (including air pollution, climate changes etc..), and gene of the association between ocular disorders and systemic diseases (cardiovascular disease, kidney disease etc..). 2. To explore lifestyle factors (dietary habit, sleep, physical activity etc..) of the association between ocular disorders and systemic diseases. Scientific rationale: With the rapid industrialization and urbanization, air quality problems and other environmental health troubles are particularly becoming major sources of morbidity and mortality in human. In the context of global climate change, accumulating epidemiological evidence indicates that abnormal ambient temperatures could increase the risk of death from a wide range of diseases. Environmental factors, such as air pollution, climate changes etc., affect the prevalence of the ocular disorders and systemic diseases. During the past few years, researchers have examined lifestyle, particularly those related to dietary habits, physical activity, and sleep, for individuals at increased incidence for ocular disorders and systemic diseases. However, little is known about whether environment and lifestyle regulate the association between ocular disorders and systemic diseases. What's more, gene-environment interactions which identify potential opportunities for personalized health interventions for individuals who are genetically susceptible to ocular disorders and systemic diseases, are not clear in the associations between ocular disorders and systemic diseases. Duration of the project: 36 months. Public health impact: This project will benefit millions of people worldwide, who are at risk of ocular disorders and systemic diseases. Of note, prevention is most effective when people at high risk are identified early, allowing preventative and therapeutic interventions. Early diagnosis and intervention in ocular disorders and systemic diseases have resulted in reducing onset, slowing the loss of function, delaying complications, improving patient quality of life, and reducing socioeconomic burden associated with the disease in the long run.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9696 | Determinants of incident atherosclerotic cardiovascular disease events among individuals with type 2 diabetic microvascular complications in the UK: a prospective cohort study | Yaxin Wang (+12) | 2023 | Diabetology & Metabolic Syndrome |
| 10139 | Evaluation of the Observational Associations and Shared Genetics Between Glaucoma With Depression and Anxiety | Xiayin Zhang (+19) | 2024 | Investigative Ophthalmology & Visual Science |
Enabling scientific discoveries that improve human health