| Title: | Higher dietary magnesium intake and lower risks of all-cause, cardiovascular and kidney disease mortality in diabetes participants: A large cross-population cohort study |
| Journal: | Diabetic Medicine |
| Published: | 23 Jan 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41578652/ |
| DOI: | https://doi.org/10.1111/dme.70223 |
Publication 18494
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
AIMS: To assess the associations between dietary magnesium intake and mortality from all-cause, cardiovascular disease (CVD) and kidney disease (KD) among participants with diabetes mellitus (DM).</p>
METHODS: The study covered 6004 adults with DM from the National Health and Nutrition Examination Survey (US NHANES) and 10,130 adults with DM from the UK Biobank. We employed Cox regression models and restricted cubic spline models to evaluate relationships between daily dietary magnesium intake and mortality from all-cause, CVD and KD.</p>
RESULTS: We documented 1442 deaths in the US NHANES and 651 deaths in the UK Biobank, respectively. When comparing the highest versus the lowest quartile of dietary magnesium intake, the adjusted hazard ratios (HR) were 0.62 (95% CI 0.50-0.78), 0.54 (95% CI 0.37-0.80) and 0.22 (95% CI 0.06-0.82) for all-cause mortality, CVD mortality and KD mortality in the US NHANES, respectively. Similarly, the adjusted HR were 0.71 (95% CI 0.57-0.88) and 0.65 (95% CI 0.43-0.98) for all-cause mortality and CVD mortality in the UK Biobank. The dietary magnesium intake exhibited a significant non-linear 'L-shaped' relationship with all-cause mortality rates in both cohorts and CVD mortality rates in the UK cohort (all p for non-linearity <0.05).</p>
CONCLUSIONS: Higher dietary magnesium intake was consistently associated with reduced risks of all-cause, CVD and KD mortality in US adults with DM and with lower all-cause and CVD mortality in UK adults with DM. These findings highlight the potential prognostic benefit of dietary magnesium intake in DM management.</p>
16 Authors
- Kaiyi Chi
- Yinglan Liang
- Yemin Li
- Zehao Luo
- Renyu Li
- Binghua Zhang
- Yican Ying
- Yi Wen
- Yiru He
- Yunying Xing
- Zhaolin Xiao
- Wenting Yang
- Zhijuan Luo
- Xiayin Zhang
- Honghua Yu
- Qiaowei Wu
1 Application
| Application ID | Title |
|---|---|
| 86091 | Regulators of the association between ocular disorders and systemic diseases. |
Enabling scientific discoveries that improve human health