| Application: | 17689, Genetic, environmental and lifestyle predictors of brain/cognitive-related outcomes. |
| Title: | Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity |
| Size: | 250916 B |
| Archived: | 2 Nov 2020 |
| Stability: | Complete |
| Personal: | No individual-level data |
Return 2728
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Notes
Apolipoprotein e4 genotype is found in around 25% of the population, and is a known risk factor for increased risk of dementia.However, there is lack of large-scale, high quality data relating to how it affects brain structure and function in generally healthy, non-demented brains.
Here, we looked at e4 genotype presence vs. absence, and found that it mostly associates with brain white matter hyperintensity volumes. It did not associate with gray matter, particularly.
This means that at least in non-pathological ageing, APOE e4 seems to be affecting the brain through mostly a vascular-type health pathway (which is reflects to some extent by hyperintensity volume).
Application 17689
Genetic, environmental and lifestyle predictors of brain/cognitive-related outcomes.
The project aims to integrate genetic, biomarker, brain imaging and cognitive/mood data to give a complete 'picture' of what predicts, mediates and moderates worse mental ability and mood disorder in UK Biobank, cross-sectionally and prospectively using follow-up data. We will research this question using UK Biobank cognitive test, brain MRI (structural and functional), biomarker (i.e. assay), mood-related and cognitive data, using formal tests of association, mediation and moderation. We will use the primary care and HES data in order to ascertain follow-up mood disorders. Our project meets UK Biobank?s stated purpose of improving the prevention, diagnosis and treatment of illnesses by identifying risk factors for lower cognitive ability and mood disorder; important risk factors for physical ill health, earlier mortality and lower quality of life. Insights from this work will lead to a better understanding of disease processes in cognitive decline and Alzheimer's disease (dementia) and mood disorders such as depression, including better approaches to diagnosis and ultimately the development of new treatments. The work will consist of using genome-wide association (GWA) data in the UK Biobank, together with environmental variables e.g. sociodemographics, and lifestyle variables e.g. health related behaviours like smoking status, alcohol intake etc., to test for independent associations with cognitive abilities and mood disorders, both at baseline and at follow-up, based on NHS record linkage. We will test for how these associations are mediated by brain MRI variables, and/or moderated by biomarker variables (e.g. lipid levels, inflammatory markers). The project will make full use of phenotypic, genetic, raw/derived brain MRI/fMRI and biomarker data in the full cohort (as and when each aspect becomes available).
| Lead investigator: | Dr Donald Lyall |
| Lead institution: | University of Glasgow |
6 related Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3402 | 17689 | Alzheimer's Disease Susceptibility Gene Apolipoprotein E (APOE) and Blood Biomarkers in UK Biobank (N = 395,769) | 11 May 2021 |
| 2704 | 17689 | Assessing for interaction between APOE e4, sex, and lifestyle on cognitive abilities | 30 Oct 2020 |
| 3403 | 17689 | Association of systolic blood pressure and body mass index with cognitive and structural brain phenotypes in UK Biobank | 11 May 2021 |
| 3404 | 17689 | PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study | 11 May 2021 |
| 2729 | 17689 | Social engagement after stroke - is it relevant to cognitive function? A cross-sectional analysis of UK Biobank data | 2 Nov 2020 |
| 2590 | 17689 | The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank | 27 Oct 2020 |
1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 2729 | Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity | Donald M. Lyall (+13) | 2019 | Brain Imaging and Behavior |
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