| Title: | Circulating 25-hydroxyvitamin D concentration can predict bowel resection risk among individuals with inflammatory bowel disease in a longitudinal cohort with 13 years of follow-up |
| Journal: | International Journal of Surgery |
| Published: | 25 Mar 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38526503/ |
| DOI: | https://doi.org/10.1097/js9.0000000000001369 |
Publication 10059
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Abstract
BACKGROUND: Although the beneficial properties of vitamin D in anti-inflammation and immunity-modulation are promising in the management of inflammatory bowel disease (IBD), data were limited for the critical IBD prognosis. The association between serum vitamin D levels and the risk of bowel resection in individuals with IBD remains largely unknown.</p>
MATERIALS AND METHODS: The authors performed a longitudinal cohort study among 5474 individuals with IBD in the UK Biobank. Serum 25-hydroxyvitamin D [25(OH)D] was measured using direct competitive chemiluminescent immunoassay. Bowel resection events were ascertained via national inpatient data. Multivariable-adjusted Cox proportional hazard regression was used to examine the association between serum 25(OH)D and bowel resection risk, presented with hazard ratios (HRs) and 95% CIs. Restricted cubic spline (RCS) was used to evaluate dose-response associations.</p>
RESULTS: During a mean follow-up of 13.1 years, the authors documented 513 incident bowel resection cases. Compared to participants with vitamin D deficiency, nondeficient participants showed a significantly reduced bowel resection risk in IBD (HR 0.72, 95% CI: 0.59-0.87, P =0.001), Crohn's disease (CD, HR 0.74, 95% CI: 0.56-0.98, P =0.038), and ulcerative colitis (UC, HR 0.73, 95% CI: 0.57-0.95, P =0.020). When comparing extreme quintiles of 25(OH)D level, participants with IBD showed a 34% reduced risk of bowel resection (95% CI: 11-51%, P =0.007) and participants with UC showed a 46% reduced risk (95% CI: 19-64%, P =0.003), while this association was not significant in CD (HR 0.93, 95% CI: 0.59-1.45, P =0.740). Linear dose-response associations were observed using the RCS curve (all P -nonlinearity>0.05).</p>
CONCLUSION: Increased serum level of 25(OH)D is independently associated with reduced bowel resection risk in IBD. This association was significant in UC but may not be stable in CD. Vitamin D deficiency is a risk factor for bowel resection in individuals with IBD, and may be an effective metric in predicting and risk-screening surgical events.</p>
14 Keywords
- Adult
- Aged
- Cohort Studies
- Female
- Follow-Up Studies
- Humans
- Inflammatory Bowel Diseases
- Longitudinal Studies
- Male
- Middle Aged
- Risk Factors
- United Kingdom
- Vitamin D
- Vitamin D Deficiency
9 Authors
- Lintao Dan
- Sidan Wang
- Xuejie Chen
- Yuhao Sun
- Tian Fu
- Minzi Deng
- Jie Chen
- Zhongyan Du
- Xiaoyan Wang
1 Application
| Application ID | Title |
|---|---|
| 73595 | Comorbidities and Systemic Inflammation Related Outcomes of Inflammatory Bowel Disease |
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