| Title: | Higher Fiber Intake is Associated with Reduced Risk of Related Surgery among Individuals with Inflammatory Bowel Disease in a Prospective Cohort Study |
| Journal: | Journal of Nutrition |
| Published: | 15 Jun 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37330142/ |
| DOI: | https://doi.org/10.1016/j.tjnut.2023.06.013 |
| Citations: | 3 (3 in last 2 years) as of 8 Aug 2024 |
Publication 7796
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Abstract
BACKGROUND: Evidence for the effects of dietary fiber on adverse outcomes in individuals with inflammatory bowel disease (IBD) is insufficient and controversial.</p>
OBJECTIVES: We aimed to prospectively explore the association between dietary fiber intake and the risk of IBD-related surgery.</p>
METHODS: We identified 5580 individuals with diagnosed IBD [Crohn disease (CD, n = 1908) and ulcerative colitis (UC, n = 3672)] at baseline in the UK Biobank via electronic medical records and self-reported information. Dietary fiber intake was estimated by a partial fiber score derived from a valid food frequency questionnaire. IBD-related surgery (enterotomy, perianal surgery, and others) was ascertained via inpatient data. Cox proportional model was applied to estimate hazard ratios with 95% confidence intervals (CIs) of dietary fiber in quartiles for the risk of IBD-related surgery.</p>
RESULTS: During a mean follow-up period of 11.2 y, we documented 624 IBD-related surgery among 5580 individuals with IBD (mean age, 57.3; 52.8% females). Compared with individuals in the lowest quartiles, those with second to fourth quartiles of fiber intake were associated with 23% (95% CI: 5%, 38%, P = 0.015), 29% (95% CI: 11%, 43%, P = 0.003), and 28% (95% CI: 10%, 43%, P = 0.005) reduced risk (P-trend = 0.002) of IBD-related surgery. Similar associations were observed in CD (P-trend = 0.005) but not UC (P-trend = 0.131). We observed inverse associations of fiber in vegetables and fruits (P-trend = 0.017 and 0.007) but positive associations of fiber in bread (P-trend = 0.046) with the risk of IBD-related surgery.</p>
CONCLUSIONS: Higher intake of fiber is associated with reduced IBD-related surgery risk in patients with IBD with CD but not UC.</p>
7 Authors
- Minzi Deng
- Lintao Dan
- Shuyu Ye
- Xuejie Chen
- Xiaoyan Wang
- Li Tian
- Jie Chen
1 Application
| Application ID | Title |
|---|---|
| 73595 | Comorbidities and Systemic Inflammation Related Outcomes of Inflammatory Bowel Disease |
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